2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-124318
    SMPH Crosslinker 367927-39-7
    SMPH Crosslinker is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    SMPH Crosslinker
  • HY-140898
    Biotin-PEG7-amine 1334172-76-7 98.0%
    Biotin-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG7-amine
  • HY-W067509
    m-PEG3-CH2CH2COOH 67319-28-2
    m-PEG3-CH2CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG3-CH2CH2COOH
  • HY-140278
    DBCO-PEG4-PFP ester
    DBCO-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG4-PFP ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG4-PFP ester
  • HY-140809
    Azido-PEG4-(CH2)3OH 2028281-87-8
    Azido-PEG4-(CH2)3OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-(CH2)3OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-(CH2)3OH
  • HY-138727
    Mal-amido-PEG3-acid 2055353-75-6 98.0%
    Mal-amido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG3-acid
  • HY-135306
    Cl-C6-PEG4-C3-COOH 2127391-58-4 99.65%
    Cl-C6-PEG4-C3-COOH is a PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).
    Cl-C6-PEG4-C3-COOH
  • HY-140023
    Propargyl-PEG4-CH2COOH 1429934-37-1
    Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-CH2COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-CH2COOH
  • HY-138451
    Amino-PEG7-C2-SH hydrochloride 98.0%
    Amino-PEG7-C2-SH hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG7-C2-SH hydrochloride
  • HY-W040270
    Amino-PEG10-amine 928292-69-7
    Amino-PEG10-amine, a PEG-based PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer.
    Amino-PEG10-amine
  • HY-W063924
    Bpin-Cyclohexene-C-COOEt 1166829-70-4
    Bpin-Cyclohexene-C-COOEt is a PROTAC linker. Bpin-Cyclohexene-C-COOEt can be used in synthesis PROTAC SMARCA2/4-degrader-8 (HY-159460).
    Bpin-Cyclohexene-C-COOEt
  • HY-133192
    Bis-propargyl-PEG3 126422-58-0 98.88%
    Bis-propargyl-PEG3 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG3 is used in the synthesis of zinc-dipicolylamine (ZnDPA) complexes with antiplasmodial activity . Bis-propargyl-PEG3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG3
  • HY-130651
    5-Hexynal 29329-03-1
    5-Hexynal (compound 3) is a PROTAC linker that can be used to prepare the PROTAC product iRucaparib-TP3 (HY-130645).
    5-Hexynal
  • HY-138717
    m-PEG13-azide 98.0%
    m-PEG13-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG13-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG13-azide
  • HY-W042657
    Octaethylene glycol monomethyl ether 25990-96-9 99.84%
    Octaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Octaethylene glycol monomethyl ether
  • HY-141107
    m-PEG13-NHS ester 3063847-98-0
    m-PEG13-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG13-NHS ester
  • HY-130578
    m-PEG2-azide 215181-61-6
    m-PEG2-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG2-azide
  • HY-140721
    Mal-PEG-mal (MW 5000)
    Mal-PEG-mal (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG-mal (MW 5000)
  • HY-133396
    Azido-PEG11-azide 1392284-57-9 98.0%
    Azido-PEG11-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG11-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG11-azide
  • HY-138336
    Br-PEG3-MS 2702323-73-5
    Br-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Br-PEG3-MS
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.